The victims were identified as Adrian Mitchell and Jamie Alvarez.
According to reports, the accident occurred just after 12am on Wednesday along the Churchill Roosevelt Highway near the Cumuto traffic lights.
Reports say the driver of the car attempted to make a U-turn at the lights when he lost control of the vehicle and collided with a truck.
Both occupants of the car died on impact with the truck.
Alvarez was the niece of Soca star Bunji Garlin. He tweeted: "Rest in peace my niece. Rest in peace. May the lord strengthen Eric and Joella in this time and the rest of us. May the lord see over this and guide all our actions accordingly. The grief is heavy but knowing your are in a better place eases the pain for a few. We love you Jamie. Rest peacefully."
Arima police are investigating.